The myelin basic proteins are a set of peripheral membrane polypeptides which play an essential role in myelination. Their most well‐documented property is the unique ability to ‘seal’ the cytoplasmic aspects of the myelin membrane, but this is probably not the only function for these highly charged molecules. Despite extensive homology, the individual myelin basic proteins (MBPs) exhibit different expression patterns and biochemical properties, and so it is now believed that the various isoforms are not functionally equivalent in myelinating cells. (...) We now think that while the major MBPs are intracellular adhesion molecules, some of the quantitatively less abundant isoforms that are expressed very early in development may have regulatory effects on the myelination program. (shrink)

Written by some of the world's leading academics and professionals in the field, this collection of essays brings together two complementary views on child development - the role of society and the role of cognitive growth.

If you trained someone to emit a particular sound at the sight of something red, another at the sight of something yellow, and so on for other colors, still he would not yet be describing objects by their colors. Though he might be a help to us in giving a description. A description is a representation of a distribution in a space (in that of time, for instance).

INTRODUCTION Linguists who work within the tradition of transformational generative grammar tend to regard semantics as an intractable, perhaps ultimately ...

This article reprints the text of a review of adam smith's "theory of moral sentiments", And presents arguments for ascribing it to david hume. Hume's subsequent criticism of what he called "the hinge" of adam smith's moral system ("viz." that "all kinds of sympathy are necessarily agreeable") is also examined, And it is argued that smith failed to appreciate the nature and extent of this criticism. It is concluded that "the hinge" of smith's novel theory is a false assumption; (...) yet without it smith cannot present a viable alternative to hume's explanation of the origin of our moral sentiments. (shrink)

The strongest arguments for the permissibility of geoengineering (also known as climate engineering) rely implicitly on non-ideal theory—roughly, the theory of justice as applied to situations of partial compliance with principles of ideal justice. In an ideally just world, such arguments acknowledge, humanity should not deploy geoengineering; but in our imperfect world, society may need to complement mitigation and adaptation with geoengineering to reduce injustices associated with anthropogenic climate change. We interpret research proponents’ arguments as an application of a particular (...) branch of non-ideal theory known as “clinical theory.” Clinical theory aims to identify politically feasible institutions or policies that would address existing (or impending) injustice without violating certain kinds of moral permissibility constraints. We argue for three implications of clinical theory: First, conditional on falling costs and feasibility, clinical theory provides strong support for some geoengineering techniques that aim to remove carbon dioxide from the atmosphere. Second, if some kinds of carbon dioxide removal technologies are supported by clinical theory, then clinical theory further supports using those technologies to enable “overshoot” scenarios in which developing countries exceed the cumulative emissions caps that would apply in ideal circumstances. Third, because of tensions between political feasibility and moral permissibility, clinical theory provides only weak support for geoengineering techniques that aim to manage incoming solar radiation. (shrink)

The typical kind of color realism is reductive: the color properties are identified with properties specified in other terms (as ways of altering light, for instance). If no reductive analysis is available — if the colors are primitive sui generis properties — this is often taken to be a convincing argument for eliminativism. That is, realist primitivism is usually thought to be untenable. The realist preference for reductive theories of color over the last few decades is particularly striking in light (...) of the generally anti-reductionist mood of recent philosophy of mind. The parallels between the mind—body problem and the case of color are substantial enough that the difference in trajectory is surprising. While dualism and non-reductive physicalism are staples, realist primitivism is by and large a recent addition to the color literature. And it remains a minority position, although one that is perhaps gaining support. In this paper, we investigate whether it should be accepted, and conclude it should not be. (shrink)

This article examines the evolution of bioethics over the past four decades since the publication of John Harris’ seminal work, “The Value of Life” (1985). It argues that while the core principles articulated by Harris remain relevant, bioethics has undergone significant transformation across four key domains. First, the expanding frontiers of biotechnology have necessitated engagement with complex issues beyond individual clinical ethics. Second, there has been a widening of the circle of moral concern to encompass nonhuman animals, disability rights, and (...) global health equity. Third, bioethics has become increasingly entangled with public policy and governance. Finally, the field has seen substantial academic proliferation and institutionalization. These developments have pushed bioethics to adapt its frameworks and methodologies while maintaining fidelity to foundational principles. This article concludes by considering the future challenges and opportunities for bioethics in an increasingly complex technological and social landscape. (shrink)

This article reviews recent work aimed at developing a new framework, based on signal detection theory, for understanding the relationship between explicit (e.g., recognition) and implicit (e.g., priming) memory. Within this framework, different assumptions about sources of memorial evidence can be framed. Application to experimental results provides robust evidence for a single-system model in preference to multiple-systems models. This evidence comes from several sources including studies of the effects of amnesia and ageing on explicit and implicit memory. The framework allows (...) a range of concepts in current memory research, such as familiarity, recollection, fluency, and source memory, to be linked to implicit memory. More generally, this work emphasizes the value of modern computational modelling techniques in the study of learning and memory. (shrink)

A small proportion of clinical strains of Candida albicans undergo white–opaque switching. Until recently it was not clear why, since most strains carry the genes differentially expressed in the unique opaque phase. The answer to this enigma lies in the mating process. The majority of C. albicans strains are heterozygous for the mating type locus MTL (a/α) and cannot undergo white–opaque switching. However, when these cells undergo homozygosis at the mating type locus (i.e., become a/a or α/α), they can switch, (...) and they must switch in order to mate. Even though the newly identified stages of mating mimic those of Saccharomyces cerevisiae, the process differs in its dependency on switching, and the effects switching has on gene regulation. This unique feature of C. albicans mating appears to be intimately intertwined with its pathogenesis. The unique, newly discovered dependencies of switching on homozygosis at the MTL locus and of mating on switching are, therefore, reviewed within the context of pathogenesis. BioEssays 26:10–20, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

I might summarize this section by saying that the English tenses, according to this analysis, form quite a motley group. PAST, PRES and FUT serve to relate reference time to speech time, while WOULD and USED-TO behave like Priorian operators, shifting the point of evaluation away from the reference time. HAVE also shifts the point of evaluation away from the reference time, but in a more complicated way. And FUT, in contrast to PRES and PAST, is a substitution operator, putting (...) the reference time of its clause in the plate of the speech time of subordinate clauses. (shrink)

An experiment was conducted to test the effectiveness of brief instruction in information structuring (i.e., representing and integrating information) for improving the coherence of probability judgments and binary choices among intelligence analysts. Forty-three analysts were presented with comparable sets of Bayesian judgment problems before and immediately after instruction. After instruction, analysts’ probability judgments were more coherent (i.e., more additive and compliant with Bayes theorem). Instruction also improved the coherence of binary choices regarding category membership: after instruction, subjects were more likely (...) to invariably choose the category to which they assigned the higher probability of a target’s membership. The research provides a rare example of evidence-based validation of effectiveness in instruction to improve the statistical assessment skills of intelligence analysts. Such instruction could also be used to improve the assessment quality of other types of experts who are required to integrate statistical information or make probabilistic assessments. (shrink)

Time pressure has been shown to have a negative impact on ethical decision-making. This paper uses an experimental approach to examine the impact of an antecedent of time pressure, whether it is anticipated or not, on participants’ perceptions of unethical behaviour. Utilising 60 business school students at an Australian university, we examine the differential impact of anticipated and unanticipated time deadline pressure on participants’ perceptions of the likelihood of unethical behaviour occurring. We find the perception of the likelihood of unethical (...) behaviour occurring to be significantly reduced when time pressure is anticipated rather than unanticipated. The implications of this finding for both professional service organisations and tertiary institutions are considered. (shrink)

Although the importance of literacy is widely acknowledged in society and remains at the top of the political agenda, writing has been slow to establish a place in the cognitive sciences. Olson argues that to understand the cognitive implications of literacy, it is necessary to see reading and writing as providing access to and consciousness of aspects of language, such as phonemes, words and sentences, that are implicit and unconscious in speech. Reading and writing create a system of metarepresentational concepts (...) that bring those features of language into consciousness as a subject of discourse. This consciousness of language is essential not only to acquiring literacy but also to the formation of systematic thought and rationality. The Mind on Paper is a compelling exploration of what literacy does for our speech and hence for our thought, and will be of interest to readers in developmental psychology, cognitive science, linguistics, and education. (shrink)

This essay-a thesis accepted for the Cornell doctorate-consists of two parts, the first historical, the second expository and critical. Part I. traces the influences that led to the acceptance of a tripartite division of mind (intellect, feeling, will) in place of the older bipartite division. It also shows that Kant's original intention, in writing a third Critique, was to establish a priori principles of the new faculty of feeling; and argues that the combination of the Critiques of Taste and of (...) Teleology into a single Critique of Judgment was due to the fact that both alike were seen to centre round the idea of purposiveness. Part II indicates the need of mediation, formal and real, between the two Critiques of theoretical and of practical philosophy. The real opposition between them is to be found, primarily and chiefly, in the admission or rejection of the concept of freedom. By an elaborate analysis of Kant s theory of the beautiful, and a discussion of his use of the principle of teleology as applied to organic nature, the author is able to make it clear that the Critique of Judgment effects the desired real reconciliation. A concluding section suggests that Kant would have allowed objective validity to the teleological principle, had not the table of categories in the K. d. r. V. been already complete. -Mind [1898]. (shrink)

Over the past decade or so, several commentators have called for mission-driven research programs on solar geoengineering, also known as solar radiation management (SRM) or climate engineering. Building on the largely epistemic reasons offered by earlier commentators, this paper argues that a well-designed mission-driven research program that aims to evaluate solar geoengineering could promote justice and legitimacy, among other valuable ends. Specifically, an international, mission-driven research program that aims to produce knowledge to enable well-informed decision-making about solar geoengineering could (1) (...) provide a more effective way to identify and answer the questions that policymakers would need to answer; and (2) provide a venue for more efficient, effective, just, and legitimate governance of solar geoengineering research; while (3) reducing the tendency for solar geoengineering research to exacerbate international domination. Thus, despite some risks and limitations, a well-designed mission-driven research program offers one way to improve the governance of solar geoengineering research relative to the ‘investigator-driven’ status quo. (shrink)

Throughout his life J. J. Thomson was committed to a mechanical interpretation of nature. This work proceeded in several stages. Early in his career he attempted a Lagrangian formulation of mechanics. But due to certain epistemological difficulties with this approach, he began exploring various analogies and models, particularly those involving vortex motion. After his discovery of the electron in 1897, he commenced a synthesis of the electron with his previous physical conceptions. The result was a hypothesis of the ether as (...) being composed of particles even smaller than electrons. (shrink)

David Bloor has claimed that Wittgenstein is best read as offering the beginnings of a sociological theory of knowledge, despite Wittgenstein's reluctance to view his work this way. This leads him to dismiss Wittgenstein's many self?characterizations as mere ?prejudice?. In doing so, however, Bloor misses the import of Wittgenstein's work as a ?grammatical investigation?. The problems inherent in Bloor's interpretative approach can be discerned in his attitude toward Wittgenstein's use of imaginary scenarios: he demands that they be replaced by (...) real natural history and real ethnography. This demand is misplaced. The very self?characterizations Bloor dismisses show how imaginary scenarios have a place in his philosophical project simply by being imagined. Three examples are examined and presented in such a way as to make Bloor's demand for replacement increasingly more difficult to comprehend: while in the first case, the demand seems simply beside the point, in the second and third cases, it becomes difficult to say just what would count as replacements. Wittgenstein's imaginary scenarios are thus best read not as suggestions for further empirical research, but as devices to aid in recovering the naturalness and familiarity of our concepts, which is precisely what one would expect from them as part of a grammatical investigation. (shrink)

This third installment in David Breed's intellectual biography of Ralph Wendell Burhoe focuses upon the impact of his thought on the Unitarian Universalist Association and that group's role in Burhoe's career. Dana McLean Greeley, elected president of the American Unitarian Association in 1958, was a key figure in Burhoe's eventual participation in the project, “The Free Church in a Changing World.” Burhoe's emphasis on the need for doctrine that could communicate religious wisdom in terms of science stood in tension (...) with free‐church tradition. Nevertheless, the section of the project's final report, titled “Theology and the Frontiers of Learning,” largely accepted Burhoe's program for a new natural theology based on science. This project brought Burhoe's program to the attention of the denomination and led to the invitation in 1964 from Malcolm Sutherland, on behalf of Meadville/Lombard Theological School in Chicago, of which he was president, for Burhoe to implement his program in the new curriculum of that school. Burhoe accepted. (shrink)

Colour has often been supposed to be a subjective property, a property to be analysed orretly in terms of the phenomenological aspects of human expereince. In contrast with subjectivism, an objectivist analysis of color takes color to be a property objects possess in themselves, independently of the character of human perceptual expereince. David Hilbert defends a form of objectivism that identifies color with a physical property of surfaces - their spectral reflectance. This analysis of color is shown to provide (...) a more adequate account of the features of human color vision than its subjectivist rivals. The author's account of colro also recognises that the human perceptual system provides a limited and idiosyncratic picture of the world. These limitations are shown to be consistent with a realist account of colour and to provide the necessary tools for giving an analysis of common sense knowledge of color phenomena. (shrink)

The decision tree of life is colossal. While physicists and metaphysicians explore the possibility that the multiverse grows larger at every decision, it is the ethicist’s lot to consider the paths chosen. That is to say, ethics is generally concerned with the build-up to a decision point. But what happens afterwards? And how do our choices influence our future decision-making?

The final lines of Deleuze and Guattari’s What is Philosophy? call for a non-philosophy to balance and act as a counterweight to the task of philosophy that had been described by them in terms of concept creation. In a footnote, Deleuze and Guattari mention François Laruelle’s project of non-philosophy, but dispute its efficacy in terms of the designated relationship between non-philosophy and science, as had been realised by Laruelle at the time. However, the mature non-philosophy of Laruelle could indicate a (...) resolution to the problematic relationship between science and educational philosophy that we have inherited due to the poststructural theories of Foucault, Derrida and Deleuze. Non-philosophy suggests a framework for thought that includes science in a non-positivist style and provides the means to view education as a performative practice. This article explores the non-philosophy of Laruelle in education as a means to view education under the conditions of strict immanence and in line with an anti-phenomenological metaphysics of non-representation. Laruelle is perhaps one of the most important critics of Deleuze in France, and as such, his insights into the Deleuzian oeuvre reveal a way forward for education as a practice that analyses science, philosophy and politics through non-philosophy. (shrink)